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Both patients had substantial,sustained improvement in motor function and became much more independent.Postperatively,the second patient's maintenance dose of levodopa was decreased to 150 mg daily,which was 30 percent of the original dose.Striatal uptake of fluorodopa was unchanged 5 to 6 months postoperatively but was markedly and bilaterally increased at 12 to 13 and 22 to 24 months in both patients,closely paralleling the patients'clinical improvement.There were no serious complications. Bilateral implantation of fetal mesencephalic tissue can induce substantial long-term functional improvement in patients with parkinsonism and severe dopamine depletion and is accompanied by increased uptake of fluorodopa by the striatum.The results in these patients resemble those obtained in MPTP-treated primates and suggest that this will be a useful model for the assessment of transplantation therapies in parkinson's disease. |
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activities of daily living
activities of daily living scale
brain transplantation
CAT scan,emission
CAT scan,emission,abnormal
fetal tissue
MPTP
Parkinson disease
Parkinson disease,drug induced
Parkinson disease,surgical treatment of
Parkinson disease,treatment of
substantia nigra tissue
treatment of neurologic disorder
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